Non sedating allergy

Cetirizine is a metabolite of hydroxyzine and a selective peripheral histamine H1-receptor antagonist.

It is used for symptomatic treatment of seasonal and perennial allergic rhinitis and for chronic urticaria.

Histamine produced increases vascular permeability, causing fluid to escape from capillaries into tissues, which leads to the classic symptoms of an allergic reaction — a runny nose and watery eyes. Antihistamines suppress the histamine-induced wheal response (swelling) and flare response (vasodilation) by blocking the binding of histamine to its receptors or reducing histamine receptor activity on nerves, vascular smooth muscle, glandular cells, endothelium, and mast cells.

Itching, sneezing, and inflammatory responses are suppressed by antihistamines that act on H1-receptors.

Cetirizine, (2-(4-((4-Chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)acetic Acid, Acetic acid, (2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-, cetirizine, Cetirizine [Chemical/Ingredient], CETIRIZINE, Cetirizine (product), Cetirizine (substance)A piperidine histamine H1-receptor antagonist with anti-allergic properties and without sedative effects.

A second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria.

Some second-generation antihistamines, notably cetirizine, can interact with CNS psychoactive drugs such as bupropion and benzodiazepines.-antihistamines are among first-line therapy to treat gastrointestinal conditions including peptic ulcers and gastroesophageal reflux disease. Most side effects are due to cross-reactivity with unintended receptors.

Cimetidine, for example, is notorious for antagonizing androgenic testosterone and DHT receptors at high doses.

(NCI)A potent second-generation histamine H1 antagonist that is effective in the treatment of allergic rhinitis, chronic urticaria, and pollen-induced asthma.

Unlike many traditional antihistamines, it does not cause drowsiness or anticholinergic side effects.

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